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Antibody Therapies Targeting Complex Membrane Proteins Review

Georgina To´a Salazar, Ziyi Huang, Ningyan Zhang, Xue-Guang Zhang, Zhiqiang An,

Engineering 2021, Volume 7, Issue 11,   Pages 1541-1551 doi: 10.1016/j.eng.2020.11.013

Abstract:

In analyses of protein families that may serve as drug targets, membrane-associated G-protein-coupledconditions is illustrated by the limited number of approved biologics for targeting GPCRs and other complexChallenges in developing antibodies to complex membrane proteins such as GPCRs, ion channels, transportersThis review describes the advantages and challenges of targeting complex membrane proteins with antibodiesand discusses the preparation of membrane protein antigens and antibody generation, illustrated by select

Keywords： Antibody therapy     Complex membrane protein     Ion channels     Transporters     Membrane-bound enzymes     GPCRs    

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Effect of protein on PVDF ultrafiltration membrane fouling behavior under different pH conditions: interface

Xudong WANG,Miao ZHOU,Xiaorong MENG,Lei WANG,Danxi HUANG

Frontiers of Environmental Science & Engineering 2016, Volume 10, Issue 4, doi: 10.1007/s11783-016-0855-9

Abstract: pH values of the BSA solution significantly impact the process of membrane fouling.Dramatic flux decline is caused by membrane–BSA adhesion force at start of filtration.XDLVO theory shows the polar or Lewis acid–base interaction plays a major role in membrane fouling.membrane–BSA, which illustrated that the more hydrophilic the membrane was, the better antifouling abilitymembrane fouling by changing the AB component of free energy.

Keywords： PVDF membrane     Membrane fouling     Adhesion force     Protein     Interfacial free energy    

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Construction and humoral immune response of Epstein-Barr virus latent membrane protein 2 DNA vaccine

Jianqing PAN PhD, Qin ZHANG MD, Daowen WANG MD, PhD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 390-395 doi: 10.1007/s11684-009-0087-5

Abstract: We constructed a eukaryotic expression plasmid encoding Epstein-Barr virus latent membrane protein 2

Keywords： Epstein-Barr virus     latent membrane protein 2     nasopharyngeal carcinoma     humoral immunity    

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Lignin-based electrospun nanofiber membrane decorated with photo-Fenton Ag@MIF-100(Fe) heterojunctionsfor complex wastewater remediation

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 7,   Pages 930-941 doi: 10.1007/s11705-023-2309-9

Abstract: Membrane technology for wastewater remediation has aroused wide interest owing to its unique propertiesHowever, it remains challenging to explore green, efficient and robust membrane material and techniquefor complex wastewater treatment.Moreover, the hybrid membrane showed an excellent dye removal with degradation of 99% methylene blueapplication of green, sustainable and versatile membrane materials and technologies for efficient complex

Keywords： lignin     electrospinning     heterojunctions     photo-Fenton catalysis     wastewater remediation    

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Application of ultra-sonication, acid precipitation and membrane filtration for co-recovery of protein

Liangliang WEI,Kun WANG,Xiangjuan KONG,Guangyi LIU,Shuang CUI,Qingliang ZHAO,Fuyi CUI

Frontiers of Environmental Science & Engineering 2016, Volume 10, Issue 2,   Pages 327-335 doi: 10.1007/s11783-014-0763-9

Abstract: the processes of ultra-sonication and acid precipitation, and then the humic acid was recovered via membrane

Keywords： sewage sludge     co-recovery     proteins     humic acid     recycling     biodegradation rate    

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Transmembrane transport of polycyclic aromatic hydrocarbons by bacteria and functional regulation of membrane

Hongqi Wang, Ruhan Jiang, Dekang Kong, Zili Liu, Xiaoxiong Wu, Jie Xu, Yi Li

Frontiers of Environmental Science & Engineering 2020, Volume 14, Issue 1, doi: 10.1007/s11783-019-1188-2

Abstract: Analyze functional regulation of membrane proteins inthe transmembrane transport.mechanisms behind the microbial breakdown of polycyclic aromatic hydrocarbons (PAHs), including the role of membraneexplains the adsorption, uptake and transmembrane transport of PAHs by bacteria, the regulation of membraneprotein function during the transmembrane transport.Finally, recognize the microscopic mechanism of PAHs biodegradation in terms of cell and membrane proteins

Keywords： hydrocarbons     Transmembrane transport     Adsorption and uptake of hydrocarbons     Proteomics     Functional regulation of membraneprotein     Single cell analysis technology    

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Facile fabrication of dolomite-doped biochar/bentonite for effective removal of phosphate from complex

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 6, doi: 10.1007/s11783-023-1671-7

Abstract:

● Dolomite-doped biochar/bentonite was synthesized for phosphate removal.

Keywords： Biochar-bentonite composite     Dolomite doping     Phosphate adsorption     Polymeric matrix membrane     Adsorption-filtration    

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Systems understanding of plant–pathogen interactions through genome-wide protein–protein interaction

Hong LI,Ziding ZHANG

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 2,   Pages 102-112 doi: 10.15302/J-FASE-2016100

Abstract: great opportunity to explore plant–pathogen interactions from a systems perspective and studies on protein–protein

Keywords： plant–pathogen interactions     systems biology     omics     plant immunity     protein–protein interaction     network    

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GID complex regulates the differentiation of neural stem cells by destabilizing TET2

Frontiers of Medicine doi: 10.1007/s11684-023-1007-9

Abstract: Here, the protein level of TET2 was reduced by the ubiquitin-proteasome pathway during NSC differentiationinteracts with the core subunits of the glucose-induced degradation-deficient (GID) ubiquitin ligase complex, an evolutionarily conserved ubiquitin ligase complex and is ubiquitinated by itself.The protein levels of GID complex subunits increased reciprocally with TET2 level upon NSC differentiationOur results illustrated that the GID complex negatively regulates TET2 protein stability, further modulates

Keywords： TET2     GID complex     neural stem cells     differentiation of neurons    

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The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases

Yuan CHEN, Qi TIAN

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 70-76 doi: 10.1007/s11684-011-0119-9

Abstract:

Protein kinase C epsilon (PKC ?) is one of major isoforms in novel PKC family.

Keywords： protein kinase C ?     signal transduction     neurogenic disease    

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Wheat gluten protein and its impacts on wheat processing quality

Wujun MA, Zitong YU, Maoyun SHE, Yun ZHAO, Shahidul ISLAM

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 3,   Pages 279-287 doi: 10.15302/J-FASE-2019267

Abstract: Wheat grain protein is divided into gluten and non-gluten fractions and the wheat processing qualityBased on the SDS-extractability, grain protein is divided into SDS-unextractable polymeric protein (UPP) and SDS-extractable polymeric protein.

Keywords： wheat gluten     consensus motifs     disulfide bonds     SDS-unextractable polymeric protein     glutenins     gliadins     processing quality     storage protein    

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Construction of sustainable, colored and multifunctional protein silk fabric using biomass riboflavin

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 8,   Pages 1131-1139 doi: 10.1007/s11705-023-2321-0

Abstract: modification of silk fabric by impregnation with riboflavin sodium phosphate was proposed, such that protein

Keywords： biomass     riboflavin sodium phosphate     silk protein     multifunctional modification     flame retardant    

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Antithrombin deficiency and decreased protein C activity in a young man with venous thromboembolism:

Dong Wang, Min Tian, Guanglin Cui, Dao Wen Wang

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 319-323 doi: 10.1007/s11684-017-0553-4

Abstract:

Antithrombin and protein C are two crucial members in the anticoagulant system and play importantCoagulation tests revealed that the patient presented type I antithrombin deficiency combined with decreased proteinThis study demonstrates that the combination of antithrombin deficiency and decreased protein C activity

Keywords： antithrombin deficiency     protein C activity     mutation     variant     venous thromboembolism     anticoagulants    

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Interspecies transmission and evolution of the emerging coronaviruses: perspectives from bat physiology and protein

Baicheng HUANG, Kegong TIAN

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 218-226 doi: 10.15302/J-FASE-2020324

Abstract: The relationship of spatial structural characteristics of the spike protein, a protein that is critical

Keywords： bat     coronavirus     evolution     host receptor     spike protein     transmission    

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Elevated C-reactive protein levels predict worsening prognosis in Chinese patients with first-onset stroke

Jiangtao YAN, Rutai HUI, Daowen WANG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 30-35 doi: 10.1007/s11684-009-0005-x

Abstract: The role of high sensitivity C-reactive protein (hsCRP) in predicting prognosis after stroke in the Asian

Keywords： C-reactive protein     inflammation     stroke    

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Title Author Date Type Operation

Antibody Therapies Targeting Complex Membrane Proteins

Georgina To´a Salazar, Ziyi Huang, Ningyan Zhang, Xue-Guang Zhang, Zhiqiang An,

Journal Article

Effect of protein on PVDF ultrafiltration membrane fouling behavior under different pH conditions: interface

Xudong WANG,Miao ZHOU,Xiaorong MENG,Lei WANG,Danxi HUANG

Journal Article

Construction and humoral immune response of Epstein-Barr virus latent membrane protein 2 DNA vaccine

Jianqing PAN PhD, Qin ZHANG MD, Daowen WANG MD, PhD,

Journal Article

Lignin-based electrospun nanofiber membrane decorated with photo-Fenton Ag@MIF-100(Fe) heterojunctionsfor complex wastewater remediation

Journal Article

Application of ultra-sonication, acid precipitation and membrane filtration for co-recovery of protein

Liangliang WEI,Kun WANG,Xiangjuan KONG,Guangyi LIU,Shuang CUI,Qingliang ZHAO,Fuyi CUI

Journal Article

Transmembrane transport of polycyclic aromatic hydrocarbons by bacteria and functional regulation of membrane

Hongqi Wang, Ruhan Jiang, Dekang Kong, Zili Liu, Xiaoxiong Wu, Jie Xu, Yi Li

Journal Article

Facile fabrication of dolomite-doped biochar/bentonite for effective removal of phosphate from complex

Journal Article

Systems understanding of plant–pathogen interactions through genome-wide protein–protein interaction

Hong LI,Ziding ZHANG

Journal Article

GID complex regulates the differentiation of neural stem cells by destabilizing TET2

Journal Article

The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases

Yuan CHEN, Qi TIAN

Journal Article

Wheat gluten protein and its impacts on wheat processing quality

Wujun MA, Zitong YU, Maoyun SHE, Yun ZHAO, Shahidul ISLAM

Journal Article

Construction of sustainable, colored and multifunctional protein silk fabric using biomass riboflavin

Journal Article

Antithrombin deficiency and decreased protein C activity in a young man with venous thromboembolism:

Dong Wang, Min Tian, Guanglin Cui, Dao Wen Wang

Journal Article

Interspecies transmission and evolution of the emerging coronaviruses: perspectives from bat physiology and protein

Baicheng HUANG, Kegong TIAN

Journal Article

Elevated C-reactive protein levels predict worsening prognosis in Chinese patients with first-onset stroke

Jiangtao YAN, Rutai HUI, Daowen WANG

Journal Article